Fully Implantable, Wireless, Flow & Pressure Measurement System.
Flow RelationshipsIn 1985, we implanted our first tethered flowprobe in rodents. With each of the thousands that have followed, we have endeavored toward our evolutionary goal. Today, we bring you the future of telemetry. Introducing EndoGear®: the first fully implantable, wireless, blood flow and pressure measurement system.
EndoGear® Implants are configurable to meet your research needs. With 1 flowprobe (sized by target vessel) and up to 2 solid-state Scisense pressure sensors, the two most essential hemodynamic parameters are finally available to record longitudinally. Cardiac output, total peripheral resistance, stroke volume, heart rate, the full suite of pressure indices and more can be monitored continuously without interference or interruption.
Our perivascular flowprobes report true volume flow, not velocity. They have been deployed in thousands of studies of aortic, carotid, renal and mesenteric flow, just to name a few of the applications. Originally conceived and designed for chronic implantability, our flowprobes are known for dependable stability and unsurpassed resolution.
The standard of accuracy and resolution in the life science market today is the high-fidelity solid-state catheter. Our Scisense brand has offered solid-state catheter technology for pressure and pressure-volume loop measurement for years. With our latest 1.9F design, we offer our most innovative catheter yet, one that was built specifically for the demands of chronic instrumentation.
Battery life can be a weak link in telemetry systems. Our Wireless Power Supply offers thermally neutral, uninterrupted power delivery for up to two animals at a time, in a single cage. All Implant variants can be equipped with inductive technology to get the most out of your blood flow and pressure studies.
EndoGear® is also available with a 1.2Ah battery for shorter term protocols.
The EndoGear® hardware network provides a straightforward path to get your data reliably. We built this network to operate within variable lab environments and to perform to multiple study goals. Whether you are looking to collect continuous data from all subjects or measure from individual animals sequentially, we have a solution for you.
The Control Hub is a software solution from Transonic that allows for visual management of all your implants. It hosts several key features, including:
As well, the Control Hub allows for customizable scheduling for automated implant cycling in sequential data collection modes and timed monitoring for scheduled sampling when continuous 24 hour recording is not required.
EndoGear® is designed to allow data collection from multiple implants simultaneously. Depending on your experimental set-up there are two methods for arranging multi-implant data collection: simultaneous and sequential.
The introduction of wireless flow measurement opens a wide range of research possibilities and study design variations in rodent models >250g. The most common vessels for flow measurement are the carotid artery, renal artery, mesenteric artery and of course, the aorta. These targeted flow measurements can be paired with pressure assessments, either vascular and/or ventricular. EndoGear® delivers flow and pressure data - such as cardiac output and vascular resistance - you cannot get from other technologies.
Cardiac output assessment is our flagship application with EndoGear®. We feel that this measurement represents an important step forward for anyone interested in studying fundamental properties of the heart. Particularly important for drug screening assessment in safety pharmacology, longitudinal and high-resolution interrogation of stroke volume, heart rate and thus cardiac output, provides new insight into pharmaco-mediated cardiac affects. In addition to models and protocols centered in the cardiovascular system, other fields such as endocrine/metabolic and neuro can benefit from this novel assessment.
Using our familiar perivascular flowprobe design and our transit-time technology, direct volumetric assessment of stroke volume is now possible. Implanted on the ascending aorta, the non-constrictive flowprobe is sized to each animal model depending on the application timelines, animal strain, animal size and several other factors. Transit-time technology does not require contact with the vessel and therefore the flowprobe can be placed chronically while still allowing for vessel growth over the study time period. We designed these flowprobes for chronic implantation, and they have been used in this application for decades in tethered animals. By untethering this technology, subtle effects can be assessed without the stress and complications to the subject that tethered data collection can bring.
Blood pressure is the most studied hemodynamic parameter and is therefore offered by all telemetric providers. With our new Scisense solid-state catheter, high-fidelity pressure measurements can finally be paired with volumetric assessments of vascular flow. Our 1.9F catheter can be deployed in both vascular and ventricular applications and from this, vascular resistance can be assessed from a single implant, for the first time. Due to the relationship between flow and pressure, vascular resistance gives the ability to the assess net effects of vasoactive mechanisms participating in blood pressure regulation and cardiac control.
This illustration shows where each of the implant components are placed surgically. The flowprobe is placed around the ascending aorta for cardiac output measurements, while the pressure sensor is introduced in the abdominal aorta, through the iliac artery, for mean arterial pressure assessment. The implant body itself is placed in the abdominal cavity while the inductive WPR is placed in a ventral subcutaneous pocket.
