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EndoGear®

Untether your data

Fully Implantable, Wireless, Flow & Pressure Measurement System.

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  • Product Information
  • EndoGear Biotelemetry

    The Research Possibilities are Endless

    In 1985, we implanted our first tethered flowprobe in rodents. With each of the thousands that have followed, we have endeavored toward our evolutionary goal. Today, we bring you the future of telemetry. Introducing EndoGear®: the first fully implantable, wireless, blood flow and pressure measurement system.

    EndoGear® Implants

    EndoGear® integrates the two most important hemodynamic variables – volumetric blood flow and blood pressure – into a single wireless implant.  Designed for rodent models >250g and similar life science species.

    Volumetric Blood Flow

    Using the technology we pioneered, transit-time ultrasound, EndoGear® delivers blood flow measurement you can trust.  We have been building flowprobes for 40 years. It’s what we do.

    Solid-state Pressure

    Solid-state catheters are the standard of accuracy and resolution in the life science space, and we have made our own for decades.  With our newest design, we have raised the bar.

    Continuous Power

    The flexibility of telemetry without power constraints.  Get the most out of your research by collecting 24/7 data, without the concern of battery life.

    Data Acquisition that is Flexible

    With universal outputs, EndoGear® is a system built to work with most life science data acquisition providers on the market today.

    Learn More Today!

    Download our full product brochure now.

    EndoGear Implants

    EndoGear® Implants are configurable to meet your research needs. With 1 flowprobe (sized by target vessel) and up to 2 solid-state Scisense pressure sensors, the two most essential hemodynamic parameters are finally available to record longitudinally.  Cardiac output, total peripheral resistance, stroke volume, heart rate, the full suite of pressure indices and more can be monitored continuously without interference or interruption.

    Built for the Demands of Chronic Instrumentation

    EndoGear® Implants provide blood flow and pressure with power options configurable to your lab's application. The implant electronics are protected in a silicone encapsulated composite enclosure that is biocompatible. The flowprobes and sensors are designed for implant longevity. Speak with our Application Team to learn what layout would meet your needs today.

    Built for the Demands of Chronic Instrumentation

    EndoGear® Implants provide blood flow and pressure with power options configurable to your lab's application. The implant electronics are protected in a silicone encapsulated composite enclosure that is biocompatible. The flowprobes and sensors are designed for implant longevity. Speak with our Application Team to learn what layout would meet your needs today.

    Built for the Demands of Chronic Instrumentation

    EndoGear® Implants provide blood flow and pressure with power options configurable to your lab's application. The implant electronics are protected in a silicone encapsulated composite enclosure that is biocompatible. The flowprobes and sensors are designed for implant longevity. Speak with our Application Team to learn what layout would meet your needs today.

    Built for the Demands of Chronic Instrumentation

    EndoGear® Implants provide blood flow and pressure with power options configurable to your lab's application. The implant electronics are protected in a silicone encapsulated composite enclosure that is biocompatible. The flowprobes and sensors are designed for implant longevity. Speak with our Application Team to learn what layout would meet your needs today.

    Blood Flow Sensors

    Transit-time Flowprobes

    Our perivascular flowprobes report true volume flow, not velocity.  They have been deployed in thousands of studies of aortic, carotid, renal and mesenteric flow, just to name a few of the applications. Originally conceived and designed for chronic implantability, our flowprobes are known for dependable stability and unsurpassed resolution.

    Familiar Flowprobe Design

    EndoGear® Flowprobes feature our familiar non-constrictive design that allows for direct measurement of volumetric blood flow, without disrupting vessel function.  The design also allows for vessel growth throughout your protocol.

    Flowprobes to Meet your Needs

    With various flowprobe sizes and cable orientations, there is a flowprobe to meet your protocol requirements.  Flowprobes are available in 1.0mm-3.0mm lumen size, appropriate for vessels that range in outer diameter from ~0.7mm-3.0mm.

    Transit-time Ultrasound Technology

    Transit-time technology measures the time it takes for an ultrasonic signal to transit a fixed path across a vessel, both with and against the direction of blood flow, integrating these signals to calculate an accurate volume.  Transit-time provides bi-directional, continuous, and stable data.

    Application Specific Cable Lengths

    Each flowprobe is tailored to the protocol design, including cable orientation and length to match surgical requirements and animal size.

    Blood Pressure Sensors

    Solid-state Scisense Catheter

    The standard of accuracy and resolution in the life science market today is the high-fidelity solid-state catheter.  Our Scisense brand has offered solid-state catheter technology for pressure and pressure-volume loop measurement for years.  With our latest 1.9F design, we offer our most innovative catheter yet, one that was built specifically for the demands of chronic instrumentation.

    Our Newest Design

    Our 1.9F (0.63mm) absolute MEMS sensor is completely new and features a helically wound thermoplastic shaft that balances flexibility and feedback.  It includes our recessed pressure housing to minimize artifacts from surrounding tissue.

    Application Specific Catheter Lengths

    Each application is different, our Scisense catheter is designed to match them all.  Our catheter shaft is sized to your requirements, increasing or decreasing its length to make surgical deployment easier.

    Innovation and Stability

    Our unique design transitions the sensitive catheter shaft into a flexible cable to make tunneling easier, shortening the distance the pressure signal needs to travel and improves overall flexibility in protocol design. Two durable suture holes keep the catheter anchored for stable placement.

    Application Specific Cable Lengths

    Each catheter is tailored to the application design, including cable lengths to match animal size and surgical requirements. 

    Power Options

    Flexibility Without Power Constraints

    Battery life can be a weak link in telemetry systems. Our Wireless Power Supply offers thermally neutral, uninterrupted power delivery for up to two animals at a time, in a single cage.  All Implant variants can be equipped with inductive technology to get the most out of your blood flow and pressure studies.

    EndoGear® is also available with a 1.2Ah battery for shorter term protocols.

    Inductive Power

    Our Wireless Power Receiver can be equipped on all EndoGear® Implants and features application specific cable lengths for connection to the implant. 

    Wireless Power Supply

    Implanted subjects equipped with our Wireless Power Receiver are placed in standard rat cages atop the Wireless Power Supply for continuous and uniform power delivery throughout the entire cage. Power is consistent throughout all normal animal activities.

    Inductive Power

    Animals can be housed individually or cohoused with other implanted subjects.

    Communication Hardware

    Simple Hardware Solutions

    The EndoGear® hardware network provides a straightforward path to get your data reliably. We built this network to operate within variable lab environments and to perform to multiple study goals. Whether you are looking to collect continuous data from all subjects or measure from individual animals sequentially, we have a solution for you.

    Remote Transceiver

    The remote transceiver receives data from, and transmits commands to the Implant. It is designed to achieve maximum RF coverage to meet your environmental conditions.

    Implant-Transceiver Pairing

    The transceiver and implant use ISM RF communication protocols with a range of 5-10 m depending on environmental conditions.

    Transceiver-Base Station Network

    In continuous data collection mode, a transceiver interfaces with a base station to pass implant data through an ethernet connection. In sequential data collection mode, a transceiver interfaces with a multiplexer which can manage up to 16 implants for output to a base station.

    EndoGear® Base Station

    The Base Station receives data from and transmits commands to the transceiver through ethernet connection. 

    EndoGear® Base Station

    The Base Station decodes received digital data for output via universal BNC connections that are compatible to record with most life science data acquisition systems.

    EndoGear® Multiplexer

    When you wish to study a cohort of animals, recording data from each sequentially, a multiplexer can enhance the functions of the base station. Up to 16 transceivers can be plugged into a single multiplexer, which integrates with a single base station.

    EGUI Control Hub

    The Control Hub is a software solution from Transonic that allows for visual management of all your implants.  It hosts several key features, including:

    • Implant summary tabs
    • Control of all paired implants (ON/OFF)
    • Control of individual implant channels (ON/OFF)
    • Implant ID and settings files
    • Global tools to test implant functionality

    As well, the Control Hub allows for customizable scheduling for automated implant cycling in sequential data collection modes and timed monitoring for scheduled sampling when continuous 24 hour recording is not required.

     

    The Control Hub software also allows you to monitor your data directly. 

    Simultaneous versus Sequential Data Collection

    EndoGear® is designed to allow data collection from multiple implants simultaneously. Depending on your experimental set-up there are two methods for arranging multi-implant data collection: simultaneous and sequential.

    Simultaneous Data Collection

    In simultaneous data collection modes, the number of implants, transceivers and base stations are equivalent.  Data is output from the base stations to your data acquisition hardware of choice.  The benefit of simultaneous data collection is the ability to measure from all animal subjects at the same time.  Shown here are 6 implants, EndoGear® is fully scalable to meet any cohort size.

    Sequential Data Collection

    In sequential data collection modes, paired implants and transceivers plug into a multiplexer which in turn plugs into a single base station.  Data is output from the base station to your data acquisition hardware of choice, one implant is active at a time.  The benefit of sequential data collection is a reduction of communication hardware, but requires more critical oversight and management of the data files and acquisition interface. Shown here are 6 implants, 16 implants can plug into a single multiplexer.

    Implant-3Port-Pr-Fl-WPS
    FlowProbe-Detail
    Pressure Catheter detail
    Wireless Power Receiver
    BaseStation
    Rodent_Transparent-Circ-Implant
    Implant-3Port-Pr-Fl-WPS
    FlowProbe-Detail
    Pressure Catheter detail
    Wireless Power Receiver
    BaseStation
    Rodent_Transparent-Circ-Implant
  • Applications
  • EndoGear Applications

    The introduction of wireless flow measurement opens a wide range of research possibilities and study design variations in rodent models >250g. The most common vessels for flow measurement are the carotid artery, renal artery, mesenteric artery and of course, the aorta. These targeted flow measurements can be paired with pressure assessments, either vascular and/or ventricular. EndoGear® delivers flow and pressure data - such as cardiac output and vascular resistance - you cannot get from other technologies.

    Comprehensive Hemodynamic Assessment

    Cardiac output assessment is our flagship application with EndoGear®. We feel that this measurement represents an important step forward for anyone interested in studying fundamental properties of the heart. Particularly important for drug screening assessment in safety pharmacology, longitudinal and high-resolution interrogation of stroke volume, heart rate and thus cardiac output, provides new insight into pharmaco-mediated cardiac affects. In addition to models and protocols centered in the cardiovascular system, other fields such as endocrine/metabolic and neuro can benefit from this novel assessment.

    Cardiac Output

    Using our familiar perivascular flowprobe design and our transit-time technology, direct volumetric assessment of stroke volume is now possible. Implanted on the ascending aorta, the non-constrictive flowprobe is sized to each animal model depending on the application timelines, animal strain, animal size and several other factors. Transit-time technology does not require contact with the vessel and therefore the flowprobe can be placed chronically while still allowing for vessel growth over the study time period. We designed these flowprobes for chronic implantation, and they have been used in this application for decades in tethered animals. By untethering this technology, subtle effects can be assessed without the stress and complications to the subject that tethered data collection can bring.

    Vascular Resistance

    Blood pressure is the most studied hemodynamic parameter and is therefore offered by all telemetric providers. With our new Scisense solid-state catheter, high-fidelity pressure measurements can finally be paired with volumetric assessments of vascular flow. Our 1.9F catheter can be deployed in both vascular and ventricular applications and from this, vascular resistance can be assessed from a single implant, for the first time. Due to the relationship between flow and pressure, vascular resistance gives the ability to the assess net effects of vasoactive mechanisms participating in blood pressure regulation and cardiac control.

    Surgical Overview

    This illustration shows where each of the implant components are placed surgically. The flowprobe is placed around the ascending aorta for cardiac output measurements, while the pressure sensor is introduced in the abdominal aorta, through the iliac artery, for mean arterial pressure assessment. The implant body itself is placed in the abdominal cavity while the inductive WPR is placed in a ventral subcutaneous pocket.

     

     

    Speak to an Expert

  • Get Started
  • We are here to help

    At the center of our company is the belief that meaningful research is founded on dependable technology and trustworthy support. EndoGear® promises new and exciting research opportunities, and therefore also brings with it new challenges.  Our Team of application experts, each with a PhD in their respective fields, has years of experience in chronic instrumentation and surgical expertise.  We understand the important role that customized application design plays in the success of a given protocol and have designed an onboarding program to maximize successful outcomes.

    Application Review

    Join our Application Experts for one-on-one discussions related to your specific requirements. Our Team will gather all information necessary to evaluate your project and understand your study expectations.

    Product Overview

    With your requirements known and considered, our Team can suggest the best product layouts and configurations to meet your needs. We will collaborate with our Sales experts to review your options.

    On and Off-site Surgical/Equipment Training

    To get you started with your equipment, we offer surgical support for all clients.  This includes both hardware and detailed surgical training delivered by one of our Application Experts. These services can be customized to the scope of your project and includes both on-site and off-site components.

    Ongoing Support Materials

    Like all our products, EndoGear® includes a host of education materials including surgical guides, both written and visual, quick start guides and workbooks to help you get the most out of your investment.

    EndoGear® in Industry

    In addition to this standardized approach, we also offer additional services for our industry partners:

    • Surgical Implantation Services & Training
    • Data Analysis Services
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