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Scisense

Pressure-Volume Catheters

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ADV550

Pressure-Volume Loop Measurement System
Unparalleled Analysis of Cardiovascular Function
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  • Product Information
  • Technological Evolution…Accelerated.

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    Streamlined, user-friendly, and versatile. Welcome to The ADV550, the first system to allow catheter positioning via true-volume feedback, featuring a guided digital menu structure for user consistency, and as always, backed by our trusted Admittance technology.
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    The ADV550 features a new digital color display, reduced-weight micro-HDMI catheter cabling, a familiar form factor, and universal BNC data output to integrate with all life science data acquisition systems, including ADInstruments, emka TECHNOLOGIES, iWorx, Ponemah®, Notocord ™, BIOPAC®, etc.

    The Transonic ADVantage.

    With an integrated quick-start guide, The ADV550 features our new ADVantage digital workflow to streamline the data collection process. Built with the demands of laboratory environments in mind, data collection has never been easier.
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    Steer Your PV Loop Catheter with Immediate Volume Feedback.

    Admittance technology has always provided relative catheter position feedback via our ‘phase’ channel. The ADV550 builds on this foundation to provide the ultimate positional guide, ventricular volume feedback, instantly.
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    The Heart Is Changing in Real-Time, Your Technology Should Too.

    To deliver immediate volume feedback in the dynamic environment of the heart, the ADV550 monitors the myocardium’s contribution to the received data, constantly. Increases and decreases in muscle contribution throughout the cardiac cycle, positional changes, cardiac challenges, breathing artifact – the ADV550 tracks and removes them all.
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    More Data is Always Better. The ADV550 Provides Twice the Live Data.

    Where conductance systems leave you guessing, Admittance leads the way with live readout of high-fidelity pressure, ventricular volume, instantaneous muscle contribution (phase) and total conductance (magnitude). The ADV550 gives you confidence that your data is correct throughout your entire protocol.

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    Analyze Your Data on the Fly.

    With constant volume feedback, you are always in control. Get your data faster and more reliably.
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    Results Where They Matter Most.

    Load-dependent data is only part of the cardiac picture. Complex PV indices, such as the ‘End-Systolic Pressure-Volume Relationship’ (ESPVR) are essential for a full understanding of intrinsic characteristics. Only PV data can provide these indices, but there’s a catch. As you can see below, the myocardial contribution to the total signal increases significantly throughout the occlusion ramp, as one would expect. Other technologies rely on a saline bolus to infer an average muscle contribution during load-dependent conditions, only

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    Rather than rely on assumption or average, the ADV550 monitors and removes the changes throughout the occlusion ramp, giving you physiologically sound, load-independent data.
  • Catheters
  • Scisense Pressure-Volume Catheters

    Overview
    • Overview
    • 1.2F (0.40 mm)
    • 1.9F (0.63 mm)
    • 3.5F (1.17 mm)
    • 5F (1.67mm)
    • 7F (2.33mm)
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    Accuracy & Resolution. The high-fidelity, solid-state pressure sensor is the life science standard. Our Scisense pressure-volume catheters are all equipped with a MEMS sensor to deliver the data you need.
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    Emission and Reception. Volume data collection is based on signal.  All Scisense PV catheters work on the same principle, with emitting and sensing electrode pairs set at fixed distances, sized for your application needs.
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    Reduced Cost & Increased Flexibility. Variable Segment Length (VSL) technology, offered in the majority of our catheter sizes, allows one catheter to span 4 distinct electrode distances. With feedback from the ADV550, users can optimize their electrode length for each protocol - allowing one catheter to do the work of four.
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    1.2 French Pressure-Volume Catheter

      • Catheter Diameter:  1.2F (0.4 mm)
      • Suggested Subject:  Mouse
      • Pressure Sensing Technology:  Solid State MEMS
      • Single Segment Catheters
      • Model Number:  FTH-1212B
      • Recording Electrode Length
      • Suggested Minimum Ventricular Length
      • Catheter Length
      • Lumen
      • Tip Options
      • VSL Technology
      • 3.5 mm
      • ~5 mm
      • 18"(45.7 cm)
      • X
      • Straight
      • X
      • 4.0 mm
      • ~5.5 mm
      • 18"(45.7 cm)
      • X
      • Straight
      • X
      • 4.5 mm
      • ~6 mm
      • 18"(45.7 cm)
      • X
      • Straight
      • X
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    1.9 French Pressure-Volume Catheter

      • Catheter Diameter:  1.9F (0.63 mm)
      • Suggested Subject:  Rat
      • Pressure Sensing Technology:  Solid State MEMS
      • Single Segment Catheters
      • Model Number:  FTH-1912B
      • Recording Electrode Length
      • Suggested Minimum Ventricular Length
      • Catheter Length
      • Lumen
      • Tip Options
      • VSL Technology
      • 6 mm
      • ~8 mm
      • 18" (45.7 cm)
      • X
      • Straight
      • X
      • 8 mm
      • ~10 mm
      • 18" (45.7 cm)
      • X
      • Straight
      • X
      • Variable Segment Length [VSL] Catheters
      • 6 mm, 8 mm, 10 mm & 12 mm
      • ~8 mm, 10 mm, 12 mm & 14 mm
      • 18"(45.7 cm)
      • X
      • Straight
      • 8 mm, 10 mm, 12 mm & 14 mm
      • ~10 mm, 12 mm, 14 mm & 16 mm
      • 18"(45.7 cm)
      • X
      • Straight
      • 8 mm, 11 mm, 14 mm & 17 mm
      • ~10 mm, 13 mm, 16 mm & 19 mm
      • 18"(45.7 cm)
      • X
      • Straight
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    3.5 French Pressure-Volume Catheter

      • Catheter Diameter:  3.5F (1.17 mm)
      • Suggested Subject:  Rabbit & Similar
      • Pressure Sensing Technology:  Solid State MEMS
      • Variable Segment Length [VSL]Catheters
      • Model Number:  FTH-3518B
      • Recording Electrode Length
      • Suggested Minimum Ventricular Length
      • Catheter Length
      • Lumen
      • Tip Options
      • VSL Technology
      • 8 mm, 11 mm, 14 mm & 17 mm
      • ~16 mm, 19 mm, 22 mm & 25 mm
      • 24" (60.9 cm)
      • X
      • Straight
      • 11 mm, 14 mm, 17 mm & 20 mm
      • ~19 mm, 22 mm, 25 mm & 28 mm
      • 24" (60.9 cm)
      • X
      • Straight
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    5.0 French Pressure-Volume Catheter

      • Catheter Diameter:  5F (1.67 mm)
      • Suggested Subject:  Canine, Porcine & Similar
      • Pressure Sensing Technology:  Solid State MEMS
      • Variable Segment Length [VSL]Catheters
      • Model Number:  FTH-5018B
      • Recording Electrode Length
      • Suggested Minimum Ventricular Length
      • Catheter Length
      • Lumen
      • Tip Options
      • VSL Technology
      • 20 mm, 30 mm, 40 mm & 50 mm
      • ~39 mm, 49 mm, 59 mm &69 mm
      • 45" (114.3 cm)
      • X
      • Straight or Pigtail
      • 35 mm, 45 mm, 55 mm & 65 mm
      • ~54 mm, 64 mm, 74 mm & 84 mm
      • 45" (114.3 cm)
      • X
      • Straight or Pigtail
      • 50 mm, 60 mm, 70 mm & 80 mm
      • ~89 mm, 99 mm, 109 mm & 119 mm
      • 45" (114.3 cm)
      • X
      • Straight or Pigtail
      • 70 mm, 80 mm, 90 mm & 100 mm
      • ~89 mm, 99 mm, 109 mm & 119 mm
      • 45" (114.3 cm)
      • X
      • Straight or Pigtail
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    7.0 French Pressure-Volume Catheter

      • Catheter Diameter:  7F (2.33 mm)
      • Suggested Subject:  Canine, Porcine & Similar
      • Pressure Sensing Technology:  Solid State MEMS
      • Variable Segment Length [VSL]Catheters
      • Model Number:  FTH-7018B
      • Recording Electrode Length
      • Suggested Minimum Ventricular Length
      • Catheter Length
      • Lumen
      • Tip Options
      • VSL Technology
      • 30 mm, 40 mm, 50 mm & 60 mm
      • ~51 mm, 61 mm, 71 mm & 81 mm
      • 45" (114.3 cm)
      • Straight or Pigtail
      • 50 mm, 60 mm, 70 mm & 80 mm
      • ~71 mm, 81 mm, 91 mm & 101 mm
      • 45" (114.3 cm)
      • Straight or Pigtail
      • 70 mm, 80 mm, 90 mm & 100 mm
      • ~91 mm, 101 mm, 111 mm & 121 mm
      • 45" (114.3 cm)
      • Straight or Pigtail
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  • Applications
  • Comprehensive Assessment of Cardiac Function.

    Pressure-Volume loops provide both load-dependent and load-independent data in a single intervention. As our expectations from preclinical data collection and cardiovascular assessment escalate, so do the applications that rely on PV loop data. Select an application below to learn more.

    Select Your PV Loop Application.

    Closed Chest Catheterization
    • Closed Chest Catheterization
    • Open Chest Catheterization
    • Left Ventricle
    • Right Ventricle
    • Biventricular
    • Ex-vivo

    Closed Chest Catheterization: Via the Right Carotid Artery, Femoral Artery, and/or Jugular Vein.

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    Closed chest catheterization is minimally invasive, generally maintains innate respiratory physiology and is the most common deployment of PV catheters in pre-clinical research. Catheter positioning can take longer with this approach due to the navigation via the vasculature, passage through valves, and valve to apex geometry. This approach is not suitable in all scenarios such as the obstruction of the vascular access routes to the heart by protocol demands/other technologies or in scenarios where valvular function is impaired such as valve leakage studies.

    Open Chest Catheterization: Generally Via the Apex of the Heart.

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    Open chest catheterization is more invasive surgically when compared with closed chest approaches via the vasculature. However, catheter positioning is normally more swift in comparison to other insertion routes as there is more XYZ freedom within the ventricle. As the catheter does not need to navigate vasculature or valve, it is well suited for applications where vascular access routes are blocked and has the benefit of less wear and tear on the catheter, extending lifespan. This approach is not suitable in all scenarios however and requires subjects to be properly ventilated at all times.

    Left Ventricle.

    The assessment of cardiac inotropy (contraction) & lusitropy (relaxation) is fundamental to understanding LV performance in healthy, diseased, and pharmacological states. For the assessment of myocardial infarction, drug discovery/safety, cardiomyopathies and many other research protocols, PV loop data collection offers unrivaled scope.

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    Open chest catheterization:

     

    Access: Apex of heart
    Invasiveness: More
    Surgical Time: Similar to closed chest
    Positional Freedom: Greater XYZ
    freedom when compared with closed chest catheterization

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    Closed chest catheterization:

     

    Access: Right carotid or femoral artery
    Invasiveness: Less
    Surgical Time: Similar to open chest
    Positional Freedom: More limited 
    when compared with open chest.

    Resources

    Right Ventricle.

    Pressure Volume loop data collection is becoming increasingly common in the right ventricle, often to assess pulmonary arterial hypertension (PAH). Assessing cardiac performance and remodeling from the RV can assist determinations about pulmonary circulation, but potential applications do not end there. Sepsis research, pulmonary embolism, Acute Respiratory Distress Syndrome (ARDS), tricuspid regurgitation, and many others are showing promise.

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    Open chest catheterization:

     

    Access: Apex of heart
    Invasiveness: More
    Surgical Time: Generally faster than closed chest
    Positional Freedom: This route allows access to the long axis of the RV and with greater XYZ freedom afforded by the approach more generally, closed chest is a popular approach.

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    Closed chest catheterization:

     

    Access: Right jugular
    Invasiveness: Less
    Surgical Time: Generally slower than open chest
    Positional Freedom: Limited. The long axis of the RV cannot be accessed via this route in smaller subjects. Final position can therefore be more challenging.

    Biventricular.

    Biventricular PV Loops show broad potential.  In this approach, both ventricles are catheterized (the catheters are set to different frequencies to avoid cross talk), and pressure and volume are assessed from each.  By viewing both ventricles simultaneously and continuously, a researcher can thoroughly characterize distributed hemodynamics.

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    Open chest catheterization:

     

    Access: Apex of heart
    Invasiveness: More
    Surgical Time: Generally faster than closed chest
    Positional Freedom: Greater XYZ freedom when compared with closed chest catheterization, especially in the RV

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    Closed chest catheterization:

     

    Access: Jugular, right carotid, femoral artery
    Invasiveness: Less
    Surgical Time: Generally slower than open chest
    Positional Freedom: More limited when compared with open chest, especially in the RV.

    Ex-vivo.

    Ex-vivo cardiac research is a growing sub-category of PV data collection.  Working-heart perfusion techniques eliminate interference from the endocrine or nervous systems, allowing assessment of various cardiomyopathies, novel therapeutics, ischemia/reperfusion techniques, etc.

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    Right Ventricle:

     

    RV catheterization can be accomplished either through the perfusion infrastructure via antegrade insertion, or through the apex of the heart, depending on the perfusion system layout and study goals. Depending on the donor size, apical insertion may allow for better placement. 

     

    Access: Antegrade through the right atrium or via the apex of the heart

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    Left Ventricle:

     

    LV catheterization can be accomplished through either the perfusion infrastructure via retrograde insertion, or through the apex of the heart, depending on the perfusion system layout and study goals. 

     

    Access: Retrograde through the aortic valve or via the apex of the heart

    General Considerations: Ex-Vivo applications are varied and nuanced with a wide range of fluid types, perfusion infrastructure and study goals. Speak with one of our experts to learn more about how the ADV550 can be tailored to you exact study needs.

  • Education & Resources
  • Get Started
  • We are here to help

    Successful research depends on reliable technology and trustworthy support, so Transonic delivers both. Pressure-Volume Loop data is vast and detailed, which can be both illuminating and challenging. We understand these challenges, so whether you are new to the approach or have years of experience, we are here to help answer your questions.

    Application Review

    We are passionate about Pressure-Volume loops; it’s what we do. One of our experienced Team members would be happy to review your needs, either virtually, or on-site in your lab. We aim to gather all the necessary information to fully understand your lab’s needs and your application goals so we can help assure your success!

    Product Overview

    With your requirements known and considered, our Team can provide guidance on everything necessary for you to be successful. Including catheter sizing suggestions, PV theory background and surgical planning. 

    On and Off-site Surgical/Equipment Training

    Proper surgical technique is a fundamental part of PV loop data collection. Our Team of Application Experts, each with a PhD and years of surgical experience, have training programs designed to suit your level of expertise. With both remote and personalized hands-on training available, we offer flexible, tailored support to meet your needs.

    Ongoing Support and Learning Opportunities

    Like all our products, The ADV550 includes a host of education materials including comprehensive surgical guides/videos, technical manuals, application notes, quick start guides and of course, our popular 140-page Pressure-Volume Workbook. We also host surgical workshops throughout the world that review surgical best practices in a PV loop data collection setting, and educational webinars hosted by our clients that review the latest news from the field.

    ADV550 in Industry

    We also offer targeted services to Industry, including: 

    • Full-service data collection, including all hardware 
    • Data review and analysis packages

    Click the link below to speak with one of our Team members and learn more about how the ADV550 can help you achieve your research goals. 

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