Where conductance systems leave you guessing, Admittance leads the way with live readout of high-fidelity pressure, ventricular volume, instantaneous muscle contribution (phase) and total conductance (magnitude). The ADV550 gives you confidence that your data is correct throughout your entire protocol.
Load-dependent data is only part of the cardiac picture. Complex PV indices, such as the ‘End-Systolic Pressure-Volume Relationship’ (ESPVR) are essential for a full understanding of intrinsic characteristics. Only PV data can provide these indices, but there’s a catch. As you can see below, the myocardial contribution to the total signal increases significantly throughout the occlusion ramp, as one would expect. Other technologies rely on a saline bolus to infer an average muscle contribution during load-dependent conditions, only.
Pressure-Volume loops provide both load-dependent and load-independent data in a single intervention. As our expectations from preclinical data collection and cardiovascular assessment escalate, so do the applications that rely on PV loop data. Select an application below to learn more.
The assessment of cardiac inotropy (contraction) & lusitropy (relaxation) is fundamental to understanding LV performance in healthy, diseased, and pharmacological states. For the assessment of myocardial infarction, drug discovery/safety, cardiomyopathies and many other research protocols, PV loop data collection offers unrivaled scope.
Open chest catheterization:
Access: Apex of heart
Invasiveness: More
Surgical Time: Similar to closed chest
Positional Freedom: Greater XYZ
freedom when compared with closed chest catheterization
Closed chest catheterization:
Access: Right carotid or femoral artery
Invasiveness: Less
Surgical Time: Similar to open chest
Positional Freedom: More limited
when compared with open chest.
Pressure Volume loop data collection is becoming increasingly common in the right ventricle, often to assess pulmonary arterial hypertension (PAH). Assessing cardiac performance and remodeling from the RV can assist determinations about pulmonary circulation, but potential applications do not end there. Sepsis research, pulmonary embolism, Acute Respiratory Distress Syndrome (ARDS), tricuspid regurgitation, and many others are showing promise.
Open chest catheterization:
Access: Apex of heart
Invasiveness: More
Surgical Time: Generally faster than closed chest
Positional Freedom: This route allows access to the long axis of the RV and with greater XYZ freedom afforded by the approach more generally, closed chest is a popular approach.
Closed chest catheterization:
Access: Right jugular
Invasiveness: Less
Surgical Time: Generally slower than open chest
Positional Freedom: Limited. The long axis of the RV cannot be accessed via this route in smaller subjects. Final position can therefore be more challenging.
Biventricular PV Loops show broad potential. In this approach, both ventricles are catheterized (the catheters are set to different frequencies to avoid cross talk), and pressure and volume are assessed from each. By viewing both ventricles simultaneously and continuously, a researcher can thoroughly characterize distributed hemodynamics.
Open chest catheterization:
Access: Apex of heart
Invasiveness: More
Surgical Time: Generally faster than closed chest
Positional Freedom: Greater XYZ freedom when compared with closed chest catheterization, especially in the RV
Closed chest catheterization:
Access: Jugular, right carotid, femoral artery
Invasiveness: Less
Surgical Time: Generally slower than open chest
Positional Freedom: More limited when compared with open chest, especially in the RV.
Ex-vivo cardiac research is a growing sub-category of PV data collection. Working-heart perfusion techniques eliminate interference from the endocrine or nervous systems, allowing assessment of various cardiomyopathies, novel therapeutics, ischemia/reperfusion techniques, etc.
Right Ventricle:
RV catheterization can be accomplished either through the perfusion infrastructure via antegrade insertion, or through the apex of the heart, depending on the perfusion system layout and study goals. Depending on the donor size, apical insertion may allow for better placement.
Access: Antegrade through the right atrium or via the apex of the heart
Left Ventricle:
LV catheterization can be accomplished through either the perfusion infrastructure via retrograde insertion, or through the apex of the heart, depending on the perfusion system layout and study goals.
Access: Retrograde through the aortic valve or via the apex of the heart
General Considerations: Ex-Vivo applications are varied and nuanced with a wide range of fluid types, perfusion infrastructure and study goals. Speak with one of our experts to learn more about how the ADV550 can be tailored to you exact study needs.
We are passionate about Pressure-Volume loops; it’s what we do. One of our experienced Team members would be happy to review your needs, either virtually, or on-site in your lab. We aim to gather all the necessary information to fully understand your lab’s needs and your application goals so we can help assure your success!
With your requirements known and considered, our Team can provide guidance on everything necessary for you to be successful. Including catheter sizing suggestions, PV theory background and surgical planning.
Proper surgical technique is a fundamental part of PV loop data collection. Our Team of Application Experts, each with a PhD and years of surgical experience, have training programs designed to suit your level of expertise. With both remote and personalized hands-on training available, we offer flexible, tailored support to meet your needs.
Like all our products, The ADV550 includes a host of education materials including comprehensive surgical guides/videos, technical manuals, application notes, quick start guides and of course, our popular 140-page Pressure-Volume Workbook. We also host surgical workshops throughout the world that review surgical best practices in a PV loop data collection setting, and educational webinars hosted by our clients that review the latest news from the field.
We also offer targeted services to Industry, including:
Click the link below to speak with one of our Team members and learn more about how the ADV550 can help you achieve your research goals.
