A tightly controlled relationship between blood pressure and organ blood flow is vital for matching an organ’s metabolic needs to the delivery of oxygen and nutrients. However, the nature of the pressure-flow relationship is complex and governed by multiple control systems, including local autoregulatory mechanisms at the level of the individual organ, as well as neural and hormonal modulation. To fully understand how pressure-flow relationships operate in health, and may be altered in pathological settings, it is essential to make direct, long-term assessments of blood pressure and blood flow under normal physiological conditions (ie in the conscious state).
In this presentation, Dr. McBryde will share insights from her studies of how the relationship between blood pressure and blood flow is altered in hypertension, to “consumer” organs such as the brain, and to “supply” circulations such as the mesenteric venous pool. She will also discuss the variables that go into gathering accurate measurements of these two parameters in a lab setting.
Key learning objectives:
- Understanding the importance of assessing blood pressure and organ blood flow in tandem
- Appreciating some of the challenges in making studies physiologically and/or clinically relevant
- Gaining insight into how the pressure-flow relationship can differ between end organs and under conditions of cardiovascular disease