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Portal Vein Blood Flow Measurement during Auto Islet Cell Transplantation


Excising a diseased pancreas removes not only pancreatic cells that produce digestive enzymes but also islet of Langerhans cells that produce insulin to control blood sugar. Without insulin a patient becomes diabetic and requires lifelong use of supplemental insulin to control blood sugars. Auto islet cell transplantation takes islet of Langerhans cells from the pancreas and transplants them to the liver to reduce the diabetic risk. The removed pancreas is processed to isolate the insulin-producing islets of Langerhans cells. The isolated cells are suspended in a solution and then 800 - 1500 cc of solution is slowly infused through the splenic vein back into the liver through the portal vein where it is hoped that they will implant, grow and produce insulin to metabolize sugar.   


Flow Measurement during Islet Infusion

Surgeons measure portal venous flow during islet cell infusion to detect any sudden decrease in flow that may foreshadow a problem with the infusion. A 10 mm to 14 mm Perivascular Flowprobe is placed on the portal vein and flow is measured continuously. In this high stakes auto islet cell transplantation procedure, Transonic® Flowprobes provide a continuous volumetric measure of portal vein flow to inform the surgeon about the safety, fluidity and success of auto islet cell transplantation.

More more information check out the Portal Vein Blood Flow Measurement during Islet Cell Transplantation Medical Note.