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Researchers Develop Model to Study Ischemia-reperfusion Injury

Researchers from the institution’s Dept. of Microsurgery, and the Stem Cell Therapy Unit, led by Alberto Ballestin, recently developed an innovative new model for studying the pathophysiology of ischemia-reperfusion injury in reconstructive microsurgery (see link below). Microsurgical reconstructions are used clinically to address complex tissue defects, to replant amputations and to perform reconstruction after various cancer treatments, burns, etc. This new model will allow the evaluation of various techniques and agents that could counteract the damage caused by ischemia in these critical surgeries.

Transonic’s transit-time flow measurement, utilized in the new model, will be critical in the study of these treatment techniques and pathways. Flow measurements are clearly an integral component in the study of flow-limiting conditions such as ischemia and in confirming anastomotic patency and reperfusion. 

See: “Ischemia-reperfusion injury in a rat microvascular skin free flap model: A histological, genetic, and blood flow

study,” PLoS One. 2018 Dec 27;13(12):e0209624.