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Small Animal Cardiovascular Successful physiological measurements in small animal models depends on precise, innovative technology and proven protocols for their use. In a range of small animal models, in vivo pressure and high resolution blood flow data can be recorded with Transonic flowprobes. Applications include:
Key Small Animal Model Applications Include: Acute superior mesenteric artery flow in a mouse with a 0.7PSB flowprobe. Data courtesy of M.F. Callahan, Wake Forest University Medical College Continuous Cardiac Output: Ascending Aorta/PA: Beat-to-Beat Volume Flow Data Instantaneous flow waveforms are used for calculating average cardiac output, stroke volume, peak flow, aortic input impedance, systemic vascular resistance and heart rate. Small animal cardiac output measurements are achieved with Transonic PS-Series perivascular probes that require little isolation between the Ascending Aorta and Pulmonary Artery in order to encircle the vessel with the probe's reflector.
Carotid Arterial Blood Flow Measurement Transonic flowprobes are routinely used in rats and mice in standard protocols for thrombosis formation and lysis because of their measurement precision. Transonic Nanoprobes are the method of choice for mouse carotid artery occlusive thrombosis studies which require precision of zero blood flow to discern "time to occlusion."
Renal Arterial Blood Flow Measurement Hypertension studies rely on accurate measurement of renal blood flow and once again, Transonic flowprobes offer time-tested accuracy and reliability. Surgical protocols captured on video and powerpoint guide the researcher through implantation of a flowprobe on the renal arteries of mice and rats to achieve solid data.
Femoral Arterial Blood Flow Measurement Exercise studies have been performed in rats and are now even possible in the mouse to further explore mechanisms in genetic knockout models. The mice are recovered from flowprobe implantation and similarly tethered for measurements during exercise on a small treadmill. Researchers at Wake Forest University Health Sciences are now performing separate measurements of cardiac output, renal blood flow and femoral blood flow in subjects during exercise and after treatment with L-NAME.
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