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NIH Grant for Mouse Technology Development
April, 1999, Ithaca, NY —
Transonic Systems Inc. Receives $500,000 Two-year Phase II NIH Grant for Development of Tools & Techniques to Measure Flow & Pressure in Mice
Transgenic mouse models are increasingly important as research models but
existing commercial monitoring tools are too bulky for mouse studies and require cumbersome surgical approaches.
During the successful Phase I NIH Mouse Grant, Transonic Systems
collaborated with Thomas L. Smith at Bowman Gray School of Medicine to size the primary cardiovascular vessels in the mouse and develop prototype mouse flowprobes. The
first edition of the training manual, "Tools and Techniques for Hemodynamic Studies in the Mouse." documented pressure catheter construction and protocols for
transit time ultrasound flow measurements and laser Doppler perfusion measurements in mouse models.
The second phase of the grant will allow Transonic Systems to continue
mouse probe development, validate these new perivascular flowsensors, develop protocols and video teaching aids that will enable direct, continuous measurement of flow in
mouse vessels. The project is headed by Transonic Systems engineer, Bruce McKee. Development of the necessary measurement protocols and validation of the instruments will
continue in partnership with Thomas L. Smith and Michael Callahan from Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC.. Protocols will be
documented on video for availability to the research community. They will also be published in an updated edition of the Mouse Workbook
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Measuring Blood Flow in Mice
