Some COstatus^® Key User Comments:

Pediatric Studies

Texas Children's Hospital:

“There is good agreement in CO measurements determined by UD versus TD* in pediatric patients. The COstatus^® system provides a novel, minimally invasive method of determining real time cardiac output in children.”

Citation: I Crittendon, W Dreyer and J Kim, “Validation of ultrasound dilution cardiac output measurements in pediatric patients.” # 210, Critical Care
Medicine, Vol. 37 Supplement 12, A90, 2009.
* UD refers to COstatus^® Ultrasound Dilution measurements and TD refers to Thermodilution.

Boston Children's Hospital:

“This pilot study showed acceptable agreement in CO determined by COstatus^® and the Fick method in critically ill infants and children. COstatus^® can be used to routinely measure CO in children using existing lines.”

Citation: S Rajagopal and M Costello, “Validation of an ultrasound dilution cardiac output measurement technique in critically ill children”.
Pediatric Critical Care Colloquium, Pittsburg, PA, USA, 15-17 May 2010

Adult Studies

National Center for Hematology, Russian Federation:

“COstatus^® CO measurements were compared with pulmonary artery thermodilution measurements in adult ICU patients and in patients undergoing abdominal surgery under anesthesia with clinically acceptable results."

Citation: Galstyan G, Bychynin M, Alexanyan, M, Gorodetskiy V. “Comparison of Cardiac Output and Blood Volumes in Intrathoracic Compartments
measured by Ultrasound Dilution and Transpulmonary Thermodilution Methods”. Intensive Care Medicine (Accepted for publication).

National Research Center of Surgery, Russian Federation:

“We found that CO determined by the new COstatus^® system based on UD method and the clinical standard PA Thermodilution method is interchangeable in heterogeneous post cardiac surgery critically ill patients. Being less invasive and safe, COstatus^® has the potential to be used not only in adults but also in younger age patients.”

Citation: Eremenko AA, Safarov PN. “Flow-Regulated Extracorporeal Arteriovenous Tubing Loop for Cardiac Output Measurements by Ultrasound Velocity
Dilution: Validation in Post-Cardiac Surgery Intensive Care Unit Patients”. ASAIO (Accepted for publication).

Animal Study – Shunt Identification

Radhoud University Nijmegen Medical Center, The Netherlands:

“Cardiac output measurement with the UDCO method is reliable and easily applicable in ventilated juvenile lambs, even in the presence of a significant left-to-right shunt”.

Citation: S Vrancken, W De Boode, J Hopman, S Singh, K Liem, “Cardiac output measurement is feasible in the presence of left-to-right shunt with
ultrasound dilution method: a validation study in lambs”. Critical Care, Vol. 14 Supplement 1, P97, 2010.