Transonic Systems Inc.
top_right

Publications | Site Map

 
 
Research Surgery Critical Care Hemodialysis Radiology OEM About Contact FAQ's
 

 

 

 

 

 

Coronary BF Measurement

Continuous High Resolution Volume Flow Measurement for Acute/Chronic Research Models - PDF >

 

LCX_trace
Circumflex Coronary Artery Blood Flow in an Unanesthetized Dog day 30 after Flowprobe Implantation

Low offset and stable baseline make Transonic the technology of choice for coronary occlusion models. High resolution waveforms are unaffected by electromagnetic noise. MRI compatible non-magnetic flowprobes can be ordered. Transonic® clinical flowprobes are now used widely during CABG

  • Chronic myocardial hibernation & Ischemia models
  • Experimental revascularization
  • CABG patency and techniques
  • Stunned myocardium
  • Novel perfusion methodologies

Acute Open-Chest

  • Choose close fitting probes for ease in maintaining acoustic coupling
  • Use Transonic approved coupling gel for signal transmission
  • (HR Jelly, or Surgilube; NALCO superabsorbant)
  • Stabilize probe on beating heart with silicone coronary flange; also holds gel in place

Chronic Implant

  • Choose loose fitting probe, so that vessel fills 75%-85% of probe lumen
  • Choose "side" cable configuration for seating probe in position on vessel; provide strain relief loop in cable
  • Specify silicone coronary flange for stabilization on myocardium
  • Choose preferred chronic style connector & cable length for protocol
  • Tissue ingrowth provides excellent signal coupling

 

 

 

Coronary-Probes
Coronary Flowprobes

ProbesWFlange
Probes With Flange

Chronic-connectors
Chronic connectors

SkinButton
Skin button With Cap

PR & PS-Series Probes >

CoronaryRecs

All recommendations are based on vessel diameter estimates. Probe choice will depend on surgical approach, species and weight. MA-probes are configured for standard acute application. Order MC-probes for any customization or chronic configuration options.

PR & PS-Series Probes >
 

Example: Myocardial Ischemia and Coronary Artery Blood Flow

Species: Pig
Weight: 25 - 35 Kilo
Vessel: left circumflex coronary artery & left anterior descending coronary artery
Duration: acute
 

Recommended Probes:
2.5SB on the LAD
3SB on the LCx
Cable Length: 1 meter
Connector: CH10
Accessories: Anchor Flange
 

pig_coronweb
Conscious Pig: probe placed around the coronary artery; 3 days post-op

 

 

 

Select References

 

 

Sun, YH, Anderson TJ, Parker, KH, Tyberg, JV, “Effects of Left Ventricular Contractility and Coronary Vascular Resistance on Coronary Dynamics,” Am J Physiol Heart Circ Physiol 2004; 286(4):H1590-5. (dog, LCx, acute) (6963A)

Tune, JD, Gorman, MW, Feigl, EO, “Matching Coronary Blood Flow to Myocardial Oxygen Consumption,” Invited Review J Appl Physiol 2004;97:404-415. (dog, LAD, LCx, chronic) (6958A)

Shannon, RP, Mathier, MA, Shen, Y-T, “Coronary Vascular Responses to Short-Term Cocaine Administration in Conscious Baboons Compared with Dogs,” J Am Coll Cardiol 2000;35(5):1347-54. (baboon, dog, LAD, chronic) (6962A)

St. Louis, JD, Hughes, GC, Kypson, AP, DeGrado, TR, Donovan, CL, Coleman, RE, Yin, B, Steenbergen, C, Landolfo, KP, Lowe, JE, "An Experimental Model of Chronic Myocardial Hibernation," Ann Thorac Surg 2000;69(3):1351-1357. (pig, LCX, chronic)(1564A)

Lutter, G, Martin, J, Dern, P, Sarai, K, Olschewski, M, von Samson, P, Burkle, M, Beyersdorf, F, "Evaluation of the Indirect Revascularization Method after 3 Months Chronic Myocardial Ischemia," Eur J Cardio-Thorac Surg 2000;18(1):38-45. (pig, LAD) 1553A

Solomon, SB, Glantz, SA, “Regional Ischemia Increases Sensitivity of Left Ventricular Relaxation to Volume in Pigs,” Am J Physiol 1999;276:H1994-2005. (pig, acute)(1396A)

Molloi, S, Zhou, Y, Kassab, GS, “Regional Volumetric Coronary Blood Flow Measurement by Digital Angiography: in Vivo Validation,”Acad Radiol. 2004;11(7):757-66. (pig)(6977A)

Grund, F, Summerschild, HT, Kirkeboen, KA, Ilebekk, A, “A New Approach to Normalize Myocardial Temperature in the Open-Chest Pig Model,” J Appl Physiol 1998;84:2190-2197. (pig, acute)(1457A)

Kudej, RK, Ghaleh, B, Sato, N, Shen, Y-T, Bishop, SP, Vatner, S.F., “Ineffective Perfusion-Contraction Matching in Conscious Chronically

Instrumented Pigs with an Extended Period of Coronary Stenosis,” Circ Res 1998; 82:1199-1205. (pig, LAD, chronic)(6964A)

Rebello, SS, Blank, HS, Rote, WE, Vlasuk, GP, Lucchesi, BR, "Antithrombotic Efficacy of a Recombinant Nematode Anticoagulant Peptide (rNAP5) in Canine Models of Thrombosis after Single Subcutaneous Administration," J Pharm Experi Ther 1997;283(1)91-99. (dog, LCX, LCA, jugular vein)(1578A)

Kleen, M, Habler, O, Meisner, F, Kemming, G, Pape, A, Messmer, K, “Effects of Primary Resuscitation from Shock on Distribution of Myocardial Blood Flow,” J Appl Physiol 2000;88:373-385. (pig, LAD)(6978A)

Bednarik, JA, May, CN, "Evaluation of a Transit-Time System for the Chronic Measurement of Blood Flow in Conscious Sheep," J Appl. Physiol 1995;78(2): 524-530. (sheep, chronic)(26V)
 

 

 

 
Start receiving our
Flow Matters™ Newsletter.









 

 

 

 

 

 

Blue_Printer90

Print Page

 

 

 

 

 

 

 Surgery | Critical Care | Research | Hemodialysis | OEM | Publications | Customer Service

 

 

 ©2007 Transonic Systems Inc.  All rights Reserved. Privacy Statement