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Pharmacology explores the biological, chemical and physiological effects of drugs and therapeutic agents upon living organisms. Studies cover molecular interactions all the way up to systemic behavior. Transonic® provides a range of tools for investigating the cardiovascular impact of pharmacological agents at the organ or organism level.
- Establish comprehensive cardiac hemodynamics with pressure-volume measurements.
- Determine cardiac output using flow probes on the aorta or measure volume flow through the vessel of interest.
- Assess mean arterial pressure, pulmonary artery pressure, capillary wedge pressure, or central venous pressure with solid-state pressure catheters.
- Monitor pressure, ECG and flow/velocity simultaneously with fully implantable EndoGear® telemetry.
Safety Pharmacology continues to be a rapidly developing discipline in a regulatory-driven process to generate data to inform risk/benefit assessment for pharmacological agents. The S7A: Safety Pharmacology Studies for Human Pharmaceuticals guideline for the conduct of safety pharmacology evaluations recommends using a core battery of studies on three vital organ systems (cardiovascular, respiratory and central nervous system) to assess the potential risks of novel pharmaceuticals for human use. Transonic measurements offer insight into cardiovascular behavior during pre-clinical pharmacological studies.