General Considerations for Choosing Anesthetic Agents
A. Considerations Related to the Procedure
The type of procedure
The projected length of the procedure
The amount and type of pain/distress anticipated
Study goals (Are important parameters influenced by certain drugs?)
Survival or terminal study (agents associated with prolonged
recovery or delayed effects
may be approved for terminal studies while deemed inappropriate
for survival procedures)
B. Considerations Related to the Animal
Species and strain
General condition and underlying health problems
Age
Sex
Weight
Previous Drug Exposure
Nutritional Status
Time of day as related to circadian rhythm
Numbers of animals to be anesthetized simultaneously
Note: There can be remarkable variation in response to anesthesia.
Investigators should monitor anesthesia closely in each animal and make appropriate modifications in the anesthetic regimen when necessary
C. Considerations Related to the Drug(s) Used
Drug Safety and ease of use
Appropriateness for the procedure
Appropriateness for the animal
Side effects
Equipment and training required for safe use
Previous experience using the agent(s)
Cost and status as controlled or uncontrolled drug
Summary: Anesthetic agents should:
Provide an appropriate depth and length of anesthesia and analgesia
without affecting important study parameters
Be appropriate for the animal given its species, medical history and
physical condition
Have minimal side effects
Be safe for both the animal and the personnel administering .
Anesthesia
